Question: For adults with attention deficit hyperactivity disorder (ADHD), how effective is immediate-release methylphenidate, compared to placebo or no intervention, for improving patient outcomes?

Answer:

Limited evidence from one systematic review and a very small additional crossover trial indicates that immediate-release methylphenidate may be associated with improvements in the symptoms of ADHD (hyperactivity, impulsivity and inattention) and improvements in driving performance. However, evidence was derived mainly from small crossover trials and issues with the analysis methods mean that effect estimates from the systematic review may be unreliable. Further research is required to adequately assess the effects of immediate-release methylphenidate in adults with ADHD. In particular, studies with longer term follow-up and studies assessing possible adverse effects are needed.

To view the full summary, click the green Download Document link to the right.

To view the Cochrane review, click the link under Related Documents  below.

For relevant NICE guidelines, click the link under Related Links below.