definite clinical implications can be made from the available
evidence. Currently, there are no trials that evaluate the
effectiveness of clozapine in comparison with other treatments
exclusively in patients with rapid cycling bi-polar disorder.
Evidence that address this BEST question is based on a subgroup
analysis of a RCT - and in this analysis, only one outcome was
evaluated (Brief Psychiatric Rating Scale). Study authors noted the
need for further evidence-based research in this area, which would
help develop more targeted treatments.
BEST Question 131.pdf
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