Question:
In adults with depression, how effective is cognitive behavioural therapy (CBT) alone or combined with pharmacotherapy, compared with pharmacotherapy alone, in improving patient outcomes?
Answer:
Evidence from one systematic review and two additional
randomised controlled trials indicates that cognitive therapies may
be similarly effective to pharmacotherapy in reducing depressive
symptoms and preventing remission. Evidence from one further
randomised controlled trial indicated that the addition of
cognitive behavioural therapy to usual care (including
pharmacotherapy) may reduce symptoms of depression, panic and
anxiety and improve quality of life in people with
treatment-resistant depression.
The evidence base was limited and studies included in the
systematic review, as well as individual randomised controlled
trials, had significant methodological weaknesses. Further, high
quality research is needed to confirm the findings of these
studies. Given the nature of the intervention, investigators should
particularly consider the use of independent, blinded outcome
assessment.