Question: In adults with generalised anxiety disorder, how effective is pregabalin, compared to treatment as usual, in managing symptoms of anxiety and improving patient outcomes?

Answer:

No definite clinical implications can be made from the available evidence. The current research has not been well-reported, or has methodological limitations. Although there is some evidence to suggest that pregabalin is superior compared to placebo, data on the efficacy of pregabalin
compared to other treatments is limited. There is a general consensus among the study authors that more randomised controlled trials with long-term follow-up are needed to evaluate pregabalin, and that these studies need to consider other patient outcomes such as quality of life.