Question:
“In adults with a behavioural variant (particularly Progressive non fluent aphasia (PNFA), semantic dementia (SD), logopenic dementia) or frontotemporal dementia (FTDbv) how effective are cholinesterase inhibitors or memantine in achieving improved patient outcomes?”
Answer:
Plain language summary
Evidence suggests that more substantial high quality research is
needed into the effectiveness of cholinesterase inhibitors or
memantine, in improving symptoms of behavioural variant and
frontotemporal dementia.
Clinical and research implications
No definite clinical implications may be made based on the
evidence presented in this BEST summary. The authors of one
well-conducted paper included in this summary suggested that
memantine is not an effective treatment for frontotemporal lobar
degeneration (FTD). There was general consensus among all study
authors that there is a need to develop more effective therapeutics
for FTD.
To view the full summary, click the Download Document
link to the right.