In adults with substance or alcohol addiction, how effective are psychedelic compounds as detoxification agents, or adjunct to psychotherapies, compared to any other intervention, in reducing substance or alcohol use?
No firm conclusions can be made from the available evidence,
only four articles found psychedelic compounds to be effective for
reducing substance or alcohol abuse when used as detoxification
agents, or adjunct to psychotherapies. The need for further
research in this area was identified.
Clinical and research implications
No definite clinical implications may be made based on the
evidence presented in this BEST summary. The authors of a
systematic review stated that more data are needed to determine
whether lysergic acid diethylamide (LSD) may be beneficial or
harmful in certain subgroups of individuals. It was also suggested
that future trials should consider combining a range of doses of
LSD with current evidence-based alcohol relapse prevention
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