Question: In adults exposed to traumatic events how effective are pharmacological interventions compared to a placebo for the prevention of post-traumatic stress disorder (PTSD)?


One, well conducted Cochrane systematic review found some very limited evidence that hydrocortisone may be effective in preventing the development of post-traumatic stress disorder in adults exposed to various traumatic experiences. Evidence was derived from four small randomised controlled trials with a total of 165 participants and some methodological weaknesses.

As noted by the review authors, further research is needed to adequately assess the efficacy of hydrocortisone and other pharmacotherapies in preventing Further research is therefore needed to adequately assess the efficacy of various pharmacotherapies in preventing PTSD.


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To view the Cochrane review, click the Related Document link, below.

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