Question: In female adults with bipolar disorder are there any pharmacological interventions that are as effective or more effective than Depakote in maintaining stable mood while causing the fewest hormonal side effects (PCOS, hirsutism)?


No definite clinical implications can be made from the limited evidence. Currently there are no randomised controlled trials that evaluate the comparative effectiveness of alternative pharmacological interventions to semisodium valproate in terms of reducing hormonal side effects.

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