Question:
In adults with Alzheimer’s Disease or mixed dementia, which is the most effective Acetylcholinesterase Inhibitor in ameliorating symptoms or slowing deterioration in memory/cognition?
Answer:
No definite clinical implications can be made from the available
evidence. In order to best address the above question, head-to-head
trials of acetylcholinesterase inhibitors are required, yet very
few
good quality head-to-head studies have been conducted (as reported
by one well-conducted systematic review). Based on pairwise
comparisons, there is some evidence to suggest that donepezil,
rivastigmine and galantamine are all significantly more effective
than placebo for
cognitive outcomes.
The authors of a SR suggested that more good quality RCTs of
long-term duration are required, and that trials should aim to use
the same standardised outcomes measures. In addition, they stated
that more research into valid ways of accounting for missing data
are needed in studies that measure degenerative diseases such as
AD.