Question: In adults with borderline personality disorder how effective is antipsychotic medication compared to any other intervention, for achieving improved patient outcomes?


No definite clinical implications can be made from the available evidence. There is, however, some evidence to suggest that anti-psychotics, particularly second-generation anti-psychotics, are effective in treating patients with borderline personality disorder (BPD). The authors of a Cochrane systematic review found that there was no evidence that any drug reduces overall BPD, but found that different treatments were effective in different ways. As such, they recommended that pharmacotherapeutic treatment of BPD should be targeted at defined symptoms.

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