Question: In elderly patients with depression, how effective is Venlafaxine compared to Sertraline in terms of side effects and interactions?


No definite clinical implications can be made from the available evidence. The authors of one RCT published in 2003 suggested that venlafaxine should possibly be avoided in frail elderly until more evidence about its safety is available. The authors also stated more research is needed on the safety of drugs in the frail elderly.

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