Question: In adults with depression how effective is paroxetine compared to other anti-depressive agents for improving patient outcomes?


No definite clinical implications can be made based on the available evidence. The authors of a well-conducted systematic review suggested that there were some possible differences between paroxetine and other antidepressants, but that the clinical meaning of these differences is uncertain, and that no definitive implications for clinical practice can be drawn. They also stated that more high quality studies are needed that consider rating scales as well as pragmatic outcome measures (for example hospitalisations, return to work, social functioning, etc.).

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