Based on one systematic review of four studies in adults with
major depressive disorder, modafinil augmentation therapy showed a
positive effect on depressive symptoms at the end of treatment
compared with placebo. Given that the review was of moderate
quality but the quality of the included studies was unclear, the
overall strength of evidence for this topic is low. All the
evidence was of short-term effects of up to eight weeks and there
is a need for further research into the long-term effects of
modafinil augmentation therapy.
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