Question:
In adults with progressed dementia, how effective is analgesia, compared with any other pharmacological intervention, in decreasing behavioural and psychological symptoms, specifically aggression and agitation?
Answer:
Plain language
summary
No studies could be identified that compared pain relief
medication (Analgesia) to any other medication to measure how
effective it was in reducing aggression/agitation in people with
dementia. One study comparing pain relief to any other treatment
provided limited evidence suggesting that pain relief may be linked
to reduced agitation. Further research need to be conducted on this
topic
Clinical and research
implications
Limited evidence, from one randomised controlled trial,
indicates that the use of a pain treatment protocol may be
associated with reduced agitation (particularly verbal agitation
behaviours) compared to treatment as usual, when used in very
elderly patients with moderate to severe dementia. Two small
crossover trials, included in two systematic reviews, did not
provide significant additional evidence. No studies were identified
which compared the effectiveness of analgesia to that of other
active pharmacological interventions for behavioural
disturbance.
Further studies are needed to fully evaluate the potential
effects of pain management on behavioural disturbance in people
with dementia.
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